Table 1.
List of genes used in this analysis.
Name | Protein name | Protein class | Main function |
COL1A1 | Type I collagen alpha 1 chain | Structural component | Cartilage and connective tissue collagen |
COL1A2 | Type I collagen alpha 2 chain | Structural component | Cartilage and connective tissue collagen |
MMP1 | Matrix metalloprotease 1 (interstitial collagenase) | Protease | Cleavage of collagen I, II, and III |
MMP3 | Matrix metalloprotease 3 (stromelysin 1) | Protease | ECM component degradation |
MMP9 | Matrix metalloprotease 9 (gelatinase B) | Protease | Cleavage of collagen IV and V |
MMP13 | Matrix metalloprotease 13 (collagenase 3) | Protease | Cleavage of collagen I and III |
TIMP1 | Tissue inhibitor of metalloprotease 1 (collagenase inhibitor) | Protease inhibitor | Inhibits matrix metalloproteases, and others |
ETS1 | v-ets erythroblastosis virus E26 oncogene homolog 1 | Transcription factor | Erythroblast and fibroblast transformation |
FOS | v-fos FBJ murine osteosarcoma viral oncogene homolog | Component of AP-1 | Regulator of proliferation, differentiation, and transformation |
JUN | v-jun avian sarcoma virus 17 oncogene homolog | Component of AP-1 | Regulator of proliferation, differentiation, and transformation |
JUNB | jun B proto-oncogene | Component of AP-1 | Regulator of proliferation, differentiation, and transformation |
JUND | jun D proto-oncogene | Component of AP-1 | Regulator of proliferation, differentiation, and transformation |
NKFB1 | Subunit 1 of nuclear factor kappa-B | Component of NF-κB | Involved in many biological processes |
SMAD3 | SMA- and MAD-related protein 3 | Transcriptional modulator | Mediator of signal transduction by TGFβ1 (RSMAD) |
SMAD4 | SMA- and MAD-related protein 4 | Transcriptional modulator | Mediator of signal transduction by TGFβ1 (CoSMAD) |
SMAD7 | SMA- and MAD-related protein 7 | Transcriptional modulator | Antagonist of signalling by TGFβ1 (ISMAD) |
TNF | Tumour necrosis factor alpha | Cytokine | Proinflammatory role |
TGFB1 | Transforming growth factor beta 1 | Growth factor | Involved in proliferation and differentiation |