Table 3.

Revised Boolean functions for the simulation of TGFβ1 stimulation.

1	COL1A1.out	= TGFB1 OR FOS OR JUN	*
2	COL1A2.out	= (TGFB1 AND JUND) OR JUN	*
3	ETS1.out	= FOS AND NOT (TGFB1 AND SMAD4 AND NOT SMAD7)	*
4	FOS.out	= (TGFB1 OR (TNF AND NFKB1)) AND NOT (JUN AND FOS)
5	JUN.out	= (TNF AND JUN) OR (TGFB1 AND SMAD4 AND NOT SMAD7)
6	JUNB.out	= (TGFB1 AND NFKB1 AND SMAD4 AND NOT SMAD7) OR (TNF AND NFKB1)
7	JUND.out	= TGFB1 OR TNF OR (JUND AND NOT FOS)
8	MMP1.out	= JUND AND NOT (TGFB1 AND FOS)	*
9	MMP3.out	= (TNF AND ((ETS1 AND NFKB1) OR JUN)) OR FOS
10	MMP9.out	= TNF AND ETS1 AND NFKB1
11	MMP13.out	= (TNF AND (JUN OR NFKB1)) OR FOS
12	NFKB1.out	= TNF OR ETS1 OR NFKB1	*
13	SMAD4.out	= TGFB1	*
14	SMAD7.out	= (TGFB1 AND SMAD4 AND NOT SMAD7) OR FOS OR JUN	*
15	TIMP1.out	= (TGFB1 AND SMAD4 AND NOT SMAD7) OR (TNF AND (JUN OR JUNB OR JUND OR NFKB1)) OR FOS
16	TGFB1.out	= FOS OR JUND
17	TNF.out	= TNF AND ((ETS1 AND NFKB1) OR JUN)
18	Inactivation rule	If the transcription factors ETS1, FOS, JUN or JUNB are expressed at t > 0, they will be down- regulated at t+3 and afterwards.

Rows marked by an asterisk indicate differences of the functions for TGFβ1 and TNFα stimulation, changes to Table 2 are italicised and printed in bold. Function numbers in bold indicate omitted (1, 2, 3, 8, 9, 11, 12, 14) or inserted (18) terms.