Table 10.
Antitumor effect of taxoid 19 delivered i.v. to SCID mice bearing a Pgp+ human colon tumor xenograft, DLD-1
| Treatmenta (i.v.) |
Total Dose (mg/kg) |
Growth Delay (days) |
Toxicityc | Cured Mice/groupd |
|---|---|---|---|---|
| Control | 0 | --- | 0 | 0 / 10 |
| Vehicle | 0 | 4 | 0 | 0 / 5 |
| paclitaxel | 60 | 8 | 0 | 0 / 5 |
| 19 | 30 | 37 | 0 | 0 / 5 |
| 19 | 60 | >150 | 0 | 5 / 5 |
| 19 | 120 | >150 | 2 | 3 / 5 |
a
Treatment given IV to SCID mice on day 5 after DLD-1 human colon tumor implant, and continued as noted all drugs formulated in Tween:EtOH
b
Based on comparison of each group vs. control using the Cox-Mantel Test
c
Number of animals who either died or lost greater than 20% body weight.
d
SCID mice with no palpable tumor on day 167, end of experiment.