Figure 4. Expression patterns in breast cancer reactive stroma for genes over-expressed in prostate cancer reactive stroma.

Referring to the profiling dataset from Finak et al.(15) of normal breast stroma (n=6) and breast cancer reactive stroma (n=52), the 776 transcript probes represented in that dataset and showing over-expression in Grade 3 prostate cancer reactive stroma (Figure 2A) were examined. Top panel, gene expression heat map (genes ordered from high to low expression in reactive stroma). Bottom panel, average expression of the (mean centroid-centered) genes for the corresponding sample profiles. Unique genes (those with a common name) showing over-expression in both prostate and breast reactive stroma in indicated region (P<0.01 each dataset) are listed.