Table 2.
Significantly upregulated (p<0.01) Gene Ontology terms for genes downregulated in reactive stroma
| Category /Term | P-value | Fold |
|---|---|---|
| OXYGEN TRANSPORT | ||
| hemoglobin complex | 0.0044 | 8.6 |
| superoxide metabolic process | 0.0003 | 8.3 |
| gas transport | 0.0089 | 6.8 |
| oxygen transporter activity | 0.0089 | 6.8 |
| oxygen transport | 0.0089 | 6.8 |
| oxygen binding | 0.0067 | 4.1 |
| CYTOSKELETON | ||
| actin filament bundle | 0.0014 | 7.9 |
| stress fiber | 0.0014 | 7.9 |
| perinuclear region of cytoplasm | 0.0012 | 4.2 |
| cytoskeleton | 0.0002 | 2 |
| MUSCLE | ||
| structural constituent of muscle | 0.0002 | 5.5 |
| regulation of heart contraction | 0.0103 | 3.8 |
| contractile fiber part | 0.0092 | 3.3 |
| ION CHANNEL ACTIVITY | ||
| channel inhibitor activity | 0.0044 | 8.6 |
| ion channel inhibitor activity | 0.0044 | 8.6 |
| PROTEIN FOLDING | ||
| unfolded protein response | 0.0044 | 8.6 |
| response to protein stimulus | 0.0019 | 3.9 |
| response to unfolded protein | 0.0019 | 3.9 |
| DEVELOPMENTAL PROCESSES | ||
| ureteric bud development | 0.0006 | 9.7 |
| positive regulation of developmental process | 0.0078 | 3.4 |
| regulation of developmental process | 0.0043 | 2.2 |
| NEUROGENESIS | ||
| positive regulation of axonogenesis | 0.0057 | 7.9 |
| positive regulation of neurogenesis | 0.0089 | 6.8 |
| IMMUNE SYSTEM | ||
| leukocyte activation | 0.0049 | 2.5 |
| cell activation | 0.0057 | 2.3 |
| BEHAVIOR | ||
| learning | 0.0017 | 7.4 |
| locomotory behavior | 0.0055 | 2.2 |
| CELL MOTILITY | ||
| cell motility | 0.0010 | 2.1 |
| CELL MEMBRANE | ||
| lipid raft | 0.0099 | 4.7 |
| OTHERS | ||
| histone binding | 0.0001 | 11.2 |
| ER-nuclear signaling pathway | 0.0089 | 6.8 |
| Golgi trans face | 0.0039 | 6 |
| copper ion binding | 0.0021 | 3.9 |