Table 3.
Genes encoding growth factors, growth factor receptors, extracellular matrix proteins and matrix interacting proteins significantly upregulated in reactive stroma (p<0.01)
| Growth factor families | Name | Symbol | P-value | Fold |
|---|---|---|---|---|
| EGF | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 | ERBB2 | 0.0046 | 1.7 |
| FGF | Fibroblast growth factor 19 | FGF19 | 0.0041 | 1.7 |
| Fibronctin leucine rich transmembrane protein 1 | FLRT1 | 0.0022 | 1.8 | |
| NOTCH | Notch homolog 1, translocation-associated | NOTCH1 | 0.0078 | 1.7 |
| WNT | wingless-type MMTV integration site family, member 10B | WNT10b | 0.0023 | 1.8 |
| TGF-beta | transforming growth factor, beta receptor II | TGFBR2 | 0.0087 | 1.7 |
| KIT | v-kit feline sarcoma oncogene homolog | KIT | 0.0067 | 1.7 |
| ENDOTHELIN | endothelin receptor type B | EDNRB | 0.0058 | 1.7 |
| NEUROTROPHIN | glial cell derived neurotrophic factor | GDNF | 0.0032 | 1.8 |
| Extracellular matrix | Cartilage oliomeric matrix protein | COMP | 0.0013 | 1.8 |
| Extracellular phosphoglycoprotein with ASARM motif | MEPE | 0.0034 | 1.8 | |
| Laminin alpha chain 2, merosin | LAMA2 | 0.0077 | 1.7 | |
| Fibrinogen alpha chain | FGA | 0.005 | 1.8 | |
| Matrix interacting proteins | Syndecan 4 | SDC4 | 0.000003 | 2.3 |
| Low density lipoprotein-related protein 1 | LRP1 | 0.0086 | 1.7 | |
| Collagen Type 1 and thrombospondin receptor | CD36 | 0.0001 | 2.1 | |
| Thrombospondin 4 | THBS4 | 0.0001 | 2.1 |