Table 2.
Locus | Gene | SNP | CLP Data (p-value) | CLP + Dental Anomalies Data (p-value) |
---|---|---|---|---|
Loci where association is present in both clefts and clefts + dental anomalies data | ||||
9q22.33 | ANKS6 | rs4742741 | 0.001 | 0.0004 |
CYLC2 | rs843258 | 0.02 | 0.008 | |
GABRB2 | rs1930135 | 0.01 | 0.009 | |
TGFBR1 | rs418919 | 0.005 | 0.02 | |
FOXE1 | rs1020884 | 0.01 | 0.01 | |
FOXE1 | rs4743088 | 0.01 | 0.01 | |
17q21.1 | ERBB2 | rs1810132 | 0.0006 | 0.0006 |
ITGB3 | rs2015729 | 0.002 | 0.003 | |
ITGB3 | rs2292699 | 0.01 | 0.005 | |
1q32.3-q41 | IRF6 | rs2013162 | 0.002 | 0.002 |
IRF6 | rs674433 | 0.001 | 0.01 | |
6q21-q23 | SCML4 | rs9320231 | 0.01 | 0.006 |
BC039503 | rs6921044 | 0.01 | 0.006 | |
TCF21 | rs969282 | 0.02 | 0.008 | |
LAMA4 | rs971402 | 0.003 | 0.008 | |
MTRFL1 | rs2503791 | 0.003 | 0.009 | |
TAAR6 | rs7772821 | 0.005 | 0.01 | |
2p13 | TGFA | rs377122 | 0.04 | 0.03 |
Loci where association is stronger in the clefts + dental anomalies than that in the clefts data | ||||
5q34 | FGF18 | rs4559013 | 0.09 | 0.05 |
FGF18 | rs3934591 | 0.1 | 0.05 | |
14q24.3-q31.1 | DPF3 | rs2536143 | 0.18 | 0.03 |
NRXN3 | rs221430 | 0.32 | 0.04 | |
15q11.2-q12 | SLC12A5 | rs2879515 | 0.06 | 0.01 |
GABRB3 | rs878960 | 0.06 | 0.02 | |
GABRB3 | rs1426223 | 0.06 | 0.05 | |
LIPC | rs690 | 0.02 | 0.04 | |
20q13 | AHCY | rs819133 | 0.06 | 0.02 |
BMP7 | rs6123674 | 0.07 | 0.04 | |
21q22.11 | GART | rs4817579 | 0.16 | 0.02 |