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. Author manuscript; available in PMC: 2009 Aug 30.
Published in final edited form as: Annu Rev Biomed Eng. 2009;11:25–47. doi: 10.1146/annurev-bioeng-061008-124920

Figure 5.

Figure 5

Live-cell fluorescence imaging of the genome of bovine respiratory syncytial virus (bRSV) using molecular beacons shows the spreading of infection in host cells at days 1, 3, 5, and 7 postinfection (PI). Primary bovine turbinate cells were infected by a clinical isolate of bRSV, CA-1, with a viral titer of 2 × 103.6 TCID50 ml−1. Molecular beacons were designed to target several repeated sequences of the gene-end-intergenic-gene-start signal within the bRSV genome, with a signal-to-noise ratio of 50–200.