Skip to main content
. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Eur J Med Chem. 2009 May 21;44(10):4169–4178. doi: 10.1016/j.ejmech.2009.05.009

Figure 1.

Figure 1

The antitubercular isonicotinic acid hydrazide (1) and its Schiff base congeners (2). Position N2 of 1 is subject to deactivating acetylation by the class of enzymes known as N-arylaminoacetyl transferases (NATs). The deactivation phenomenon is associated with the rise of resistance. Compounds 2 are blocked towards this enzymatic process.