Table 1. Increased RER of lean male Mc3r^−/− mice compared to wild type littermates.

Diet	Period	Wild type	MC3R−/−	P-value
LF	Light	0.899 ± 0.007	0.902 ± 0.018	0.883
	Dark	0.925 ± 0.006	0.962 ± 0.012	0.022
	24 h	0.915 ± 0.004	0.939 ± 0.015	0.173
HF	Light	0.734 ± 0.007	0.759 ± 0.004	0.001
	Dark	0.741 ± 0.004	0.754 ± 0.040	0.041
	24 h	0.745 ± 0.005	0.762 ± 0.004	0.016

RER data recorded over a 3-day period on each diet was broken down according to light period, or per 24 h. On the low fat diet (LF), RER of Mc3r^−/− mice is significantly increased during the dark period. On the high fat diet, RER was significantly increased during the light and dark periods. This data was presented in hourly form in Fig. 3. P-values were determined by Student's t-test.