TABLE 1.
Unadjusted and age-adjusted Cox regression hazard ratios of all-cause mortality and breast cancer mortality and PAH adduct level among invasive breast cancer cases diagnosed between August 1, 1996 and July 31, 1997 (n=722) and followed-up through December 31, 2002, participating in the Long Island Breast Cancer Study Project
| All Cause Mortality (n=97 deaths) |
Breast Cancer Mortality* (n=54 deaths) |
|||||||
|---|---|---|---|---|---|---|---|---|
| No. Deaths (%) | No. Censored | Unadjusted HR† (95% CI) | Age-adjusted HR† (95% CI) | No. Deaths (%) | No. Censored | Unadjusted HR† (95% CI) | Age-adjusted HR† (95% CI) | |
| Detectable PAH-DNA adduct level | ||||||||
| No | 28 (15.0) | 159 | 1 Referent | 1 Referent | 12 (6.4) | 175 | 1 Referent | 1 |
| Yes | 69 (12.9) | 466 | 0.86 (0.55–1.33) | 0.88 (0.57–1.37) | 42 (7.9) | 493 | 1.21 (0.64–2.30) | 1.20 (0.63–2.28) |
| Quintile of PAH-DNA adduct level | ||||||||
| 1 | 28 (15.0) | 159 | 1 Referent | 1 Referent | 12 (6.4) | 175 | 1 Referent | 1 |
| 2 | 19 (14.2) | 115 | 0.95 (0.53–1.69) | 1.02 (0.57–1.84) | 12 (9.0) | 122 | 1.39 (0.63–3.10) | 1.37 (0.61–3.05) |
| 3 | 19 (14.2) | 115 | 0.95 (0.53–1.70) | 0.99 (0.55–1.77) | 10 (7.5) | 124 | 1.16 (0.50–2.69) | 1.15 (0.50–2.67) |
| 4 | 15 (11.2) | 119 | 0.74 (0.39–1.38) | 0.73 (0.39–1.36) | 9 (6.7) | 125 | 1.03 (0.43–2.44) | 1.03 (0.43–2.44) |
| 5 | 16 (12.0) | 117 | 0.80 (0.43–1.47) | 0.82 (0.44–1.52) | 11 (8.3) | 122 | 1. 7 (0.56–22.88) | 1.26 (0.56–2.86) |
*
Breast cancer reported as underlying cause of death
†
Age-adjusted hazard ratio