TABLE 2.
Effect modification of adjusted Cox regression hazard ratios of age-adjusted all-cause mortality and breast cancer mortality by age at diagnosis, hormone receptor status, menopausal status and BMI for detectable PAH adduct level among invasive breast cancer cases diagnosed between August 1, 1996 and July 31, 1997 (n=722) and followed-up through December 31, 2002, participating in the Long Island Breast Cancer Study Project
| All Cause Mortality (n=97 deaths) |
Breast Cancer Mortality* (n=54 deaths) |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Non-detects |
Detectable adducts |
Non-detects |
Detectable adducts |
|||||||||
| Stratifying Factor | No. Deaths (%) |
No. Censored |
No. Deaths (%) |
No. Censored |
Age-adjusted HR† (95% CI) |
p‡ | No. Deaths (%) |
No. Censored |
No. Deaths (%) |
No. Censored |
Age-adjusted HR† (95% CI) |
p‡ |
| Age at Diagnosis | ||||||||||||
| < 65 yr | 13 (11.4) | 101 | 37 (10.4) | 319 | 1.01 (0.54–1.89) | 0.71 | 8 (7.5) | 106 | 30 (8.4) | 326 | 1.34 (0.62–2.90) | 0.85 |
| 65+ yr | 15 (20.5) | 58 | 32 (17.9) | 147 | 0.86 (0.48–1.55) | 4 (5.8) | 69 | 12 (6.7) | 167 | 1.17 (0.38–3.63) | ||
| Hormone receptor status | ||||||||||||
| ER+/PR+ | 8 (9.4) | 77 | 17 (6.7) | 236 | 0.76 (0.33–1.76) | 0.88 | 2 (2.4) | 83 | 9 (3.6) | 244 | 1.51 (0.33–7.02) | 0.75 |
| ER+/PR− | 5 (25.0) | 15 | 12 (21.4) | 44 | 0.78 (0.27–2.22) | 2 (10.0) | 18 | 4 (7.1) | 52 | 0.69 (0.13–3.77) | ||
| ER−/PR+ | 1 (16.7) | 5 | 2 (10.0) | 18 | 0.72 (0.07–7.91) | 1 (16.7) | 5 | 2 (10.0) | 18 | 0.72 (0.07–7.92) | ||
| ER−/PR− | 6 (22.2) | 21 | 21 (27.6) | 55 | 1.21 (0.49–2.99) | 3 (11.1) | 24 | 17 (22.4) | 59 | 1.99 (0.58–6.79) | ||
| Unknown | 8 | 41 | 17 | 113 | 4 | 45 | 10 | 120 | ||||
| Menopausal Status | ||||||||||||
| Premenopausal | 5 (9.3) | 49 | 20 (11.9) | 148 | 1.51 (0.57–4.01) | 0.22 | 4 (7.4) | 50 | 16 (9.5) | 152 | 1.53 (0.52–4.55) | 0.65 |
| Postmenopausal | 23 (17.4) | 109 | 46 (13.2) | 303 | 0.78 (0.48–1.27) | 8 (6.1) | 124 | 24 (6.9) | 325 | 1.13 (0.51–2.51) | ||
| Unknown | 1 | 3 | 15 | 1 | 2 | 16 | ||||||
| BMI | ||||||||||||
| Normal (<25) | 12 (13.8) | 75 | 21 (8.8) | 218 | 0.68 (0.35–1.35) | 0.41 | 6 (6.9) | 81 | 12 (5.0) | 227 | 0.76 (0.28–2.02) | 0.41 |
| Overweight (25–29.9) | 6 (11.1) | 48 | 24 (13.9) | 149 | 1.44 (0.59–3.51) | 2 (3.7) | 52 | 13 (7.5) | 160 | 2.26 (0.52–9.88) | ||
| Obese (30+) | 10 (21.7) | 36 | 24 (19.5) | 99 | 0.91) (0.44–1.89 | 4 (8.7) | 42 | 17 (13.8) | 106 | 1.51 (0.51–4.49) | ||
| Active Cigarette Smoking | ||||||||||||
| Never | 11 (12.5) | 77 | 32 (14.0) | 197 | 1.26 (0.64–2.48) | 0.37 | 4 (4.5) | 84 | 21 (9.2) | 208 | 2.18 (0.76–6.32) | 0.43 |
| Former | 7 (12.3) | 50 | 21 (10.9) | 172 | 0.98 (0.42–2.30) | 3 (5.3) | 54 | 9 (4.7) | 184 | 0.89 (0.24–3.28) | ||
| Current | 10 (23.8) | 32 | 16 (14.2) | 97 | 0.61 (0.28–1.30) | 5 (11.9) | 37 | 12 (10.6) | 101 | 0.94 (0.33–2.67) | ||
| Active/Passive Cigarette Smoking | ||||||||||||
| Neither | 3 (12.5) | 21 | 4 (10.8) | 37 | 0.96 (0.21–4.28) | 0.33 | 2 (8.3) | 22 | 2 (5.4) | 35 | 0.66 (0.09–4.68) | 0.24 |
| Ever passive only | 7 (11.3) | 55 | 27 (14.5) | 159 | 1.44 (0.63–3.29) | 2 (3.2) | 60 | 18 (9.7) | 168 | 3.29 (0.77–14.09) | ||
| Ever active only | 3 (30.0) | 7 | 7 (16.3) | 36 | 0.40 (0.12–1.38) | 1 (10.0) | 9 | 4 (9.3) | 39 | 1.02 (0.11–9.14) | ||
| Ever both | 14 (16.3) | 72 | 26 (10.2) | 230 | 0.70 (0.37–1.34) | 7 (8.1) | 79 | 14 (5.5) | 242 | 0.68 (0.27–1.68) | ||
| Unknown | 1 | 4 | 5 | 8 | 5 | 4 | 9 | |||||
| Alcohol Consumption | ||||||||||||
| Never | 13 (18.8) | 56 | 21 (11.4) | 164 | 0.63 (0.32–1.25) | 0.18 | 7 (10.1) | 62 | 14 (7.6) | 171 | 0.74 (0.31–1.83) | 0.12 |
| Ever | 15 (12.7) | 103 | 48 (13.7) | 302 | 1.17 (0.67–2.04) | 5 (4.2) | 113 | 28 (8.0) | 322 | 2.04 (0.79–5.26) | ||
*
Breast cancer reported as underlying cause of death
†
Age-adjusted hazard ratio
‡
Interaction p-value based on likelihood ratio test.