Skip to main content
. 2009 Jul 16;28(16):2437–2448. doi: 10.1038/emboj.2009.194

Figure 7.

Figure 7

Model for dopamine regulation of the octopamine signalling in the presence and absence of food. (A) In the absence of food or food-like mechanical stimulation, dopamine is not released, and octopamine, which is released from the octopaminergic RIC neurons, is able to activate the octopamine receptor SER-3 in the SIA neurons. SER-3 works through EGL-30 (Gqα) to activates CRH-1 (CREB). (B) In the presence of food, dopamine is released and suppresses CREB activation through the D2-like dopamine receptor DOP-3 in the RIC neurons probably by decreasing octopamine release. Simultaneously, dopamine inhibits Gq signalling in the SIA neurons by activating GOA-1 (Goα) through D2-like dopamine receptors DOP-2 and DOP-3, which also results in suppression of CREB activation in the SIA neurons.