Table 2.
Summary of Literature of Familial Germ Cell Malignancy in Females
| Reference | Affected | Diagnosis | Age at diagnosis |
Other Cancers in family (age at diagnosis) |
|---|---|---|---|---|
| Jackson SM (1967) | Subject* | Mixed germ cell tumor: Chorionepithelioma/ Dysgerminoma |
26 | |
| Daughter | Dysgerminoma | 12 | ||
| Manka I (1970) | Subject | Dysgerminoma | 16 | |
| Sister | Dysgerminoma | 14 | ||
| Talerman A (1973) | Subject | Mixed germ cell tumor: Dysgerminoma/ Teratocarcinoma |
20 | |
| Sister | Dysgerminoma | 20 | ||
| Weinblatt M (1991) | Subject | Mixed GCT: Teratoma/Embryonal carcinoma |
10 | Mother: ?ovarian (17); Sister: embryonal rhabdomyosarcoma of the neck (15) |
| Sister | Embryonal carcinoma | 11 | ||
| Blake KI (1993) | Subject | Dysgerminoma | 8 | Paternal great aunt: Breast (66); Maternal great grandmother: Breast (70); Paternal great aunt: carcinoma, unknown primary (60) |
| Sister | Mixed GCT: Choriocarcinoma/Yolk sac tumor |
11 | ||
| Poremba C (1993) | Subject | Intracranial immature teratoma | 38 weeks | |
| Mother | Immature teratoma | 27 | ||
| Mandel M (1994) | Subject | Yolk sac tumor | 8 | Sister: Langerhans’ histiocytosis (2) |
| Sister | Dysgerminoma | 12 | ||
| Paternal grandmother |
Embryonal carcinoma | 65 | ||
| Stettner AR (1999) | Subject | Mixed GCT: Yolk sac tumor/ Teratocarcinoma |
26 | Mother: Breast (31) |
| Maternal Aunt | Immature teratoma | 47 | ||
| Maternal Cousin |
Mixed GCT: Choriocarcinoma/ Immature teratoma/Yolk sac tumor |
15 |
*
Maternal Grandmother reported to have ovarian cancer with unknown histology or age of diagnosis