Table 3.
Glycoprotein Biomarker Candidates for Thyroid Carcinomas
| Biomarker Candidates | Thyroid Carcinoma Subtypes | ||||||
|---|---|---|---|---|---|---|---|
| Protein Name (SwissProt Accession Number) | Papillary Thyroid Carcinoma (TPC-1) | Follicular Thyroid Carcinoma (FTC-133) | Hürthle cell Thyroid Carcinoma (XPC-1) | Anaplastic Thyroid Carcinoma (ARO) | Anaplastic Thyroid Carcinoma (DRO-1) | Expression Level in Normal Thyroida | Expression Level in Thyroid Cancera |
| CD59 (P13987) | ☑ | ☑ | ☑ | ☑ | ☑ | − | ++ |
| Basigin, CD147 (P35613) | ☑ | ☑ | ☑ | ☑ | ☑ | − | + to +++ |
| Epididymal secretory protein E1 (P61916) | ☑ | ☑ | ☑ | ☑ | ☑ | ++ | +++ |
| Galectin-3-binding protein (Q08380) | ☑ | ☑ | ☑ | ☑ | ☑ | ||
| Neutral cell adhesion molecule 1, CD56, NCAM-1 (P13591) | ☑ | ☑ | ☑ | − | + to +++ | ||
| Lactadherin (Q08431) | ☑ | ☑ | +++b +c | ++b + to + to ++c | |||
| Tetraspanin-8 (P19075) | ☑ | ||||||
| Tumor-associated calcium signal transducer 1, CD326 (P16422) | ☑ | ++ | + to +++ | ||||
| Ephrin type-B receptor 3 (P54753) | ☑ | ++d | ++ to +++d | ||||
| Ephrin-B1 (P98172) | ☑ | ||||||
| Hyaluronan and proteoglycan link protein 1(P10915) | ☑ | ||||||
| Elastin microfibril interfacer 1 (Q9Y6C2) | ☑ | − | − | ||||
| Syndecan-1 (P18827) | ☑ | − | + | ||||
| Cadherin-13 (P55290) | ☑ | − | − | ||||
| Dickkopf-3 (Q9UBP4) | ☑ | + | + to ++ | ||||
| Follistatin-related protein 1 (Q12841) | ☑ | ||||||
| Receptor-type tyrosine-protein phosphatase mu (P28827) | ☑ | ||||||
| Bone marrow stromal antigen 1, CD157 (Q10588) | ☑ | ||||||
| G-protein coupled receptor 64 (Q8IZP9) | ☑ | − | − | ||||
a
Results for Protein Atlas (http://www.proteinatlas.org/index.php) Immunohistochemical results are listed as (−) no staining or negative, (+) weak staining, (++) moderate staining, (+++) strong staining. A blank cell indicates that no information on antibody staining is available.
b
Results for antibody CAB002753
c
Results for antibody HPA002807
d
Results for antibody HPA007698