Skip to main content
. Author manuscript; available in PMC: 2010 Jul 15.
Published in final edited form as: J Immunol. 2009 Jun 26;183(2):1301–1312. doi: 10.4049/jimmunol.0803567

Figure 6. Signs of alternative macrophage activation in the lung transcriptome of macIL-10tg mice after Mtb infection.

Figure 6

(a) Gene lists identified in Fig. 5A as upregulated differentially in FVB and macIL-10tg mice at d42 after infection were entered into the Genomatix Bibliosphere literature-based data mining tool. Shown are the z-score values indicating the degree of co-citation of selected cell types with the gene list from both genotypes. Higher z-score values indicate stronger enrichment. (b) Changes in expression of selected genes associated with alternative macrophage activation during Mtb infection of FVB and macIL-10tg mice were visualized using hierarchical clustering of z-score normalized average expression values. Similarity between experimental conditions and patterns of individual genes is indicated by dendrograms. Gene symbols are given.