Skip to main content
. Author manuscript; available in PMC: 2009 Dec 1.
Published in final edited form as: Exp Gerontol. 2008 Aug 30;43(12):1086–1093. doi: 10.1016/j.exger.2008.08.050

Figure 2.

Figure 2

The effect of CR and SIRT1 knockout on the lifespan of mice with prion disease. (A) The survival of WT mice fed AL or CR and injected intracranially with RML prions (P=0.012, log rank test). (B) The survival of SIRT1 KO mice fed AL or CR injected intracranially with RML prion (P=0.002, log rank test). (C) The survival of WT and SIRT1 KO mice fed AL or CR injected intracranially with RML prions (combination of panels A and B). (D) The duration of clinical symptoms was shortened by CR independently of SIRT1. (E) Summary of the progression of prion disease for WT and SIRT1 KO fed AL or on CR. The beginning of each bar represents the onset of clinical symptoms and the end of each bar represents the terminal stage of the disease.