Table 1.
Major GO-rankings for genes differentially expressed between women and men
| Term | GoID | Unrestimulated | Stimulated | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Female Higher |
Male Higher | Female Higher |
Male Higher | ||||||
| No of Genes |
Z score |
No of Genes |
Z score |
No of Genes |
Z score |
No of Genes |
Z score |
||
| biological_process | GO:0008150 | 55 | 2.71 | 40 | 2.26 | 150 | 5.5 | 99 | 3.21 |
| cellular metabolic process | GO:0044237 | 35 | 2.85 | 17 | −0.17 | 78 | 2.28 | 56 | 1.49 |
| signal transduction | GO:0007165 | 18 | 2.16 | 10 | 0.64 | 53 | 4.59 | 31 | 2.41 |
| response to stimulus | GO:0050896 | 21 | 4.81 | 11 | 2.21 | 49 | 6.32 | 22 | 1.92 |
| cell communication | GO:0007154 | 21 | 2.65 | 10 | 0.29 | 36 | 2.97 | 60 | 4.4 |
| transcription | GO:0006350 | 6 | −0.71 | 7 | 0.56 | 30 | 2.15 | 15 | 0.15 |
| regulation of gene expression | GO:0010468 | 6 | −0.83 | 7 | 0.44 | 28 | 1.45 | 17 | 0.53 |
| cell differentiation | GO:0030154 | 17 | 4.46 | 7 | 1.16 | 25 | 2.11 | 19 | 2.26 |
| intracellular signaling cascade | GO:0007242 | 9 | 1.87 | 22 | 3.35 | 15 | 2 | ||
| immune system process | GO:0002376 | 10 | 4.1 | 9 | 4.67 | 21 | 4.7 | 15 | 4.09 |
| immune response | GO:0006955 | 9 | 4.45 | 8 | 4.91 | 20 | 5.68 | 11 | 3.79 |
| cell surface receptor linked signal transduction | GO:0007166 | 6 | 0.48 | 4 | 0.2 | 19 | 1.67 | 14 | 1.67 |
| cell death | GO:0008219 | 11 | 4.68 | 5 | 1.91 | 15 | 2.52 | 14 | 3.65 |
| apoptosis | GO:0006915 | 10 | 4.34 | 4 | 1.36 | 13 | 2.04 | 12 | 3.03 |
Gene sets with fold change ≥1.4 were analyzed using Genomatix BiblioSphere software to identify overrepresented GO groups.