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Mevalonate rescues lovastatin-induced myotube damage. Primary myotubes from wild-type mice were treated with lovastatin or lovastatin and mevalonate for 24 h. A) Morphology (left), myotube diameter (right). B) Atrogin-1 mRNA. C) Atrogin-1 protein. Mevalonate concentration was 100 μM throughout. Lovastatin concentration was 1.0 μM (A, B); 0.5 and 1.0 μM (C).
