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AGGC but not AFC mimics lovastatin-induced myotube damage. Myotubes derived from atrogin-1-knockout mice (−/−) and corresponding wild-type littermates (+/+) were treated with lovastatin (250 nM) and AGGC (15–30 μM) or AFC (10–30 μM) for 24 h. A) Morphology (left); myotube diameter, +/+ cells only (right). B) Atrogin-1 mRNA levels in +/+ cells assessed by real-time PCR. C) Atrogin-1 protein levels in +/+ cells assessed by immunoblot.
