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Open arena activity of male Cp+/+ (solid bars) and Cp−/− mice (hatched bars) after 4 weeks of manganese treatment (mean ± SE, n = 3–4). Activity was measured 6 days after the final manganese treatment, and is reported as distance traveled over 35 min (from 5 to 40 min). There was a significant manganese treatment effect (p < 0.001), but no genotype effect (p = 0.60), based on two-way ANOVA.
