FIGURE 2.

Representative microphotographic images (×1000) of normal and abnormal cell nuclei from paraffin-embedded pancreatic cancer specimens processed by fluorescence in situ hybridization (FISH). A, Patient 9 with pancreatitis showing normal FISH results for BRCA2 (orange) and LAMP1 (green). B, Patient 14 with islet cell carcinoma showing 3 FISH signals for APC (green) and EGR1 (orange) as part of a near-tetraploid condition. C, Patient 3 with acinar cell carcinoma showing amplification (≥15 target signals) of EGFR (orange) and cen 7 (green). D, Patient 5 with ductal cell adenocarcinoma showing 1 TP53 (orange) and 2 ERBB2 (green) signals, suggesting a deletion or unbalanced translocation.