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. Author manuscript; available in PMC: 2010 Jul 1.
Published in final edited form as: Neurobiol Dis. 2009 May 3;35(1):91–102. doi: 10.1016/j.nbd.2009.04.007

Table 3.

Electrophysiological parameters

Bipolar Neurons Pyramidal Neurons
Wild-Type E954Q R1648H/
E954Q		 E954Q
+STX		 R1648H/
E954Q
+STX		 Wild-Type E954Q R1648H/
E954Q		 E954Q
+STX		 R1648H/
E954Q
+STX
Voltage Dependence of Activation
Z (e0) 2.7 ± 0.9 3.2 ± 0.8 4.6 ± 1.0 2.1 ± 0.8 2.6 ± 0.7 3.0 ± 0.8 4.4 ± 1.2 4.5 ± 0.9 2.6 ± 0.8 3.0 ± 0.9
V½(mV) −28.4 ± 4.1 −29.7 ± 4.3 −30.1 ± 6.2 −24.6 ± 5.4 −24.6 ± 5.3 −26.7 ± 4.6 −26.2 ± 3.9 −28.9 ± 5.1 −20.6 ± 5.9* −20.0 ± 6.7*
n 8 10 3 4 14 9 7 8 10 7
Voltage Dependence of Inactivation
A (mV) 10.0 ± 2.1 9.7 ± 1.9 10.1 ± 1.2 20.4 ± 2.1* 19.9 ± 2.1* 7.4 ± 1.2 8.3 ± 2.8 6.8 ± 2.1 15.0 ± 3.5* 12.0 ± 3.9*
V½ (mV) −59.7 ± 8.3 −61.3 ± 7.3 −57.7 ± 6.8 −58.4 ± 7.1 −57.1 ± 5.6 −52.1 ± 7.3 −51.3 ± 6.2 −58.7 ± 8.2* −51.9 ± 7.3 −65.4 ± 9.3*
n 7 21 12 9 18 6 4 6 4 6
Recovery from Inactivation
A 0.9 ± 0.21 0.9 ± 0.16 0.9 ± 0.05 0.9 ± 0.08 0.8 ± 0.08* 0.8 ± 0.08 0.9 ± 0.07 0.9 ± 0.05 0.85 ± 0.08 0.84 ± 0.07
τ(ms) 9.4 ± 0.2 9.0 ± 0.4 12.1 ± 0.1 8.0 ± 0.2 8.0 ± 0.3 9.3 ± 0.1 11.5 ± 0.08 7.2 ± 0.06 9.2 ± 0.09 7.7 ± 0.3
c 0.1 ± 0.04 0.1 ± 0.05 0.1 ± 0.08 0.1 ± 0.02 0.2 ± 0.02* 0.1 ± 0.02 0.1 ± 0.03 0.1 ± 0.01 0.1 ± 0.07 0.2 ± 0.08*
n 6 7 6 3 13 7 5 10 4 9
Use-Dependent inactivation at 39 Hz
A1 0.4 ± 0.05 0.4 ± 0.08 0.3 ± 0.03 0.4 ± 0.08 0.25 ± 0.09 0.3 ± 0.008 0.4 ± 0.07 0.4 ± 0.03 0.3 ± 0.02 0.3 ± 0.08
A2 0.7 ± 0.06 1.0 ± 0.09 1.4 ± 0.2 1.3 ± 0.08 0.27 ± 0.04 0.9 ± 0.03 0.8 ± 0.07 0.2 ± 0.06 0.3 ± 0.02 0.4 ± 0.09
A3 1.8 ± 0.2 2.2 ± 0.8 1.1 ± 0.6 3.5 ± 0.09
τ1 (ms) 0.9 ± 0.08 0.8 ± 0.07 1.1 ± 0.1 0.9 ± 0.2 4.5 ± 0.2 0.8 ± 0.07 0.8 ± 0.08 5.9 ± 0.05 5.0 ± 0.06 3.5 ± 0.57
τ2 (ms) 0.03 ± 0.004 0.02 ± 0.001 0.02 ± 0.005 0.02 ± 0.007 0.35 ± 0.07 0.03 ± 0.004 0.03 ± 0.005 0.3 ± 0.008 0.3 ± 0.002 0.3 ± 0.01
τ3 (ms) 0.02 ± 0.006 0.02 ± 0.01 0.03 ± 0.008 0.01 ± 0.007
c 0.31 ± .08 0.25 ± 0.01 0.25 ± 0.02 0.20 ± 0.01 0.25 ± 0.03 0.22 ± 0.04
n 18 24 10 8 17 11 14 13 12 13

Parameters of voltage dependence of activation and inactivation, recovery and use-dependent inactivation of bipolar and pyramidal neurons were determined as described in the Methods.

*

indicates statistically significant differences.