Skip to main content
. Author manuscript; available in PMC: 2010 Jun 1.
Published in final edited form as: Am J Psychiatry. 2009 May 1;166(6):702–710. doi: 10.1176/appi.ajp.2008.08081201

FIGURE 3.

FIGURE 3

Reward-related consummatory activation in MDD (N=26) and comparison (N=31) subjects.

Coronal slices showing consummatory reward activity [Gain feedback - No-change feedback] in basal ganglia regions are shown for both comparison and MDD subjects, as well as for the random effect analyses comparing the two groups. Relative to comparison subjects, the MDD group shows significantly reduced activation in response to gain feedback in the (A) left nucleus accumbens and (B) bilateral caudate. Follow-up analyses on beta weights extracted from the (C) nucleus accumbens and (D) bilateral caudate regions (averaged across three clusters) indicated that group differences were specific to reward outcome. All contrasts are thresholded at p<0.005. NAcc = Nucleus Accumbens, Cd = Caudate, L = Left