Table 4.
Overlap in gene expression profiles with SSD1-V/ssd1-d
| Life-span–extending intervention | No. of genes differentially transcribed | Expression pattern | Overlap with SSD1-V/ssd1-d and the expression patterna | |
|---|---|---|---|---|
| SSD1-V/ssd1-db | 95 | 49 up | 8 | 7 up1; 1 dn |
| 46 dn | 11 | 5 dn2; 6 up | ||
| High osmolarityc | 117 | 50 up | 11 | 7 up3; 4 dn |
| 50 dn | 11 | 7 dn4; 4 up | ||
| Calorie restriction | 124 | 114 up | 19 | 15 up5; 4 dn |
| 10 dn | 0 | 0 | ||
| HAP4 overexpression | 255 | 255 up | 39 | 15 up6; 22 dn |
a Genes affected: 1. YBR131W (CCZ1), YDR534C(FIT1), YHL040C(ARN1), YKR075C, YLL053C, YLR108C, YOR383C; 2. YDL043C(PRP11), YKL096W(CWP1), YLR200W(YKE2), YMR193C-A, YPR078C; 3. YLR108C, YLR338W(OPI9), YMR169C(ALD3), YMR170C(ALD2), YMR250W(GAD1), YNR076W(PAU6), YPL223C(GRE1); 4. YBL028C, YDR152W(GIR2), YDR469W(SDC1), YGR030C(POP6), YHR055C(CUP1–2), YMR193C-A, YNL114C; 5. YDL105W(QRI2), YDR290W, YDR440W(DOT1), YDR534C(FIT1), YEL065W(SIT1), YHL040C(ARN1), YIL084C(SDS3), YIL177C, YLL011W(SOF1), YLL062C(MHT1), YNL088W(TOP2), YOR306C(MCH5), YOR374W(ALD4), YOR383C(FIT3), YPL058C(PDR12); and 6. YBL099W(ATP1), YGL149W, YGL261C(PAU11), YIL084C(SDS3), YJL102W(MEF2), YJL182C, YJR157W, YLR338W(OPI9), YLR422W, YMR007W, YOL131W, YOL166C, YPL061W(ALD6),YPL172C(COX10), YPL223C(GRE1).
b See Kaeberlein et al. (2004).
c This extends the life span of ssd1-d cells.