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S phase arrest induced by Cdc6 deficiency in nontransformed cells results from ATR-dependent DNA replication inhibition. Asynchronously growing RPE1 cells were transfected with indicated siRNA for 72 h. Transfected cells were pulse labeled with 20 μM BrdU for 15 min, fixed, CSK extracted and immunostained with indicated antibodies and DAPI (DNA). Representative nuclei from each siRNA treatment condition are shown.
