Table 3.
NMR spectral data for 9 and 10 in CDCl3.
| compound 9 | compound 10 | |||
|---|---|---|---|---|
| Position | δCa | δHb(J in Hz) | δCa | δHb(J in Hz) |
| 2 | 170.1 | 170.1 | ||
| 3 | 53.6 | 5.29 dd (8.0, 7.5) | 53.5 | 5.21 dd (7.5, 7.0) |
| 4 | 71.0 | 5.64 dq (7.5, 7.0) | 70.7 | 5.58 dq (7.5, 7.0) |
| 6 | 172.0 | 173.0 | ||
| 7 | 52.0 | 3.06 dt (10.0, 10.0) | 54.0 | 2.69 ddd (10.5, 10.0, 3.5) |
| 8 | 76.1 | 5.45 t (10.0) | 77.3 | 3.73 dt (10.0, 10.0) |
| 9 | 74.9 | 5.12 m | 76.9 | 4.87 dq (10.0, 10.0) |
| 8-OH | 1.62 br s | |||
| 4-Me | 14.8 | 1.18 d (6.5) | 14.7 | 1.15 d (7.0) |
| 9-Me | 18.0 | 1.37 d (6.5) | 18.4 | 1.47 d (6.0) |
| 1′ | 112.5 | 112.5 | ||
| 2′ | 150.6 | 150.6 | ||
| 3′ | 127.4 | 127.3 | ||
| 4′ | 124.7 | 8.52 d (8.0) | 124.8 | 8.51d (8.0 |
| 5′ | 119.0 | 6.89 t (8.0) | 119.0 | 6.88 t (8.0) |
| 6′ | 120.0 | 7.19 t (8.0) | 120.1 | 7.18 d (8.0) |
| 1′-CONH | 169.4 | 169.3 | ||
| 1′-CONH | 7.01 br d (8.0) | 7.01 d (7.5) | ||
| 2′-OH | 12.6 br s | 12.6 s | ||
| 3′-NHCHO | 7.88 br s | 7.87 br s | ||
| 3′-NHCHO | 158.9 | 8.48 s | 159.0 | 8.47 s |
| 1″a | 34.7 | 3.06 dd (20.0, 10.0) | 35.1 | 3.19 dd (13.5, 3.5) |
| 1″b | 2.78 dd (20.0, 10.0) | 2.98 dd (13.5, 10.5) | ||
| 2″ | 137.8 | 138.4 | ||
| 3″ | 128.7 | 7.09 d (7.5) | 126.6 | 7.17 d (7.5) |
| 4″ | 128.5 | 7.19 t (7.5) | 128.6 | 7.26 t (7.5) |
| 5″ | 126.6 | 7.13 t (7.5) | 128.8 | 7.16 t (7.5) |
| 6″ | 128.5 | 7.19 t (7.5) | 128.6 | 7.26 t (7.5) |
| 7″ | 128.7 | 7.09 d (7.5) | 126.6 | 7.17 d (7.5) |
| 1‴ | 165.3 | |||
| 2‴ | 129.0 | |||
| 3‴ | 129.9 | 8.05 d (8.0) | ||
| 4‴ | 128.7 | 7.48 t (8.0) | ||
| 5‴ | 133.9 | 7.62 t (8.0) | ||
| 6‴ | 128.7 | 7.48 t (8.0) | ||
| 7‴ | 129.9 | 8.05 d (8.0) | ||
a
Assignment by 13C, HSQC, and HMBC NMR methods at 125 MHz.
b
Assignment by 1H, gCOSY, gHSQC, and gHMBC NMR methods at 500 MHz.