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. Author manuscript; available in PMC: 2010 Apr 23.
Published in final edited form as: J Med Chem. 2009 Apr 23;52(8):2317–2327. doi: 10.1021/jm801110j

Table 4.

Coupling constant values for key protons on the bis-lactone ring.

3JH3-H4 3JH7-H8 3JH8-H9
compounds 1–3 7.5 Hz 10.5 Hz 10.5 Hz
compounds 4–8 7.5 Hz 10.0 Hz 10.0 Hz
compound 9 7.5 Hz 10.0 Hz 10.0 Hz
compound 10 7.5 Hz 9.0 Hz 9.0 Hz
compound 17 7.5 Hz 10.0 Hz 10.0 Hz