Table 5.
Compounds 1–10 and dexamethasone (IC50 values) for inhibition of TH2 cytokines IL-5 and IL-13 production, and cytotoxicity (LD50 values).
| IL-5 IC50 nM | IL-13 IC50 nM | Cytotoxicity LD50 nM | |
|---|---|---|---|
| Dexamethasone | 5±0.1 | 5±0.1 | >7100 |
| compound 1 | 3.1 ± 1.2 | not available | >1800 |
| compound 2 | 1.8 ± 0.2 | 1.6 ± 0.02 | >1700 |
| compound 3 | 6.7 ± 0.2 | 7.3 ± 4.2 | >560 |
| compound 4 | 47.9 ± 2.9 | 43.7 ± 3.5 | >550 |
| compound 5 | 16.6 ± 1.8 | 15.9 ± 1.1 | >570 |
| compound 6 | 9.4 ± 2.8 | 6.8 ± 0.3 | >560 |
| compound 7 | 5 ± 0.4 | 5.2 ± 0.1 | >550 |
| compound 8 | 4.3 ± 0.5 | 5.1 ± 0.1 | >1600 |
| compound 9 | 15.8 ± 1.0 | 15.2 ± 1.3 | >540 |
| compound 10 | 1022.7 ± 52.3 | 826.3 ± 187.6 | >6000 |