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. 2009 Aug 31;106(38):16357–16362. doi: 10.1073/pnas.0907996106

Fig. 5.

Fig. 5.

Effect of human MSCs or its CM on alveolar fluid clearance (A). MSCs or its CM restored the decrease in alveolar fluid clearance in the lung lobe injured by endotoxin to control values at 4 h. n = 3–4; *, P < 0.0006 vs. control AFC; †, P < 0.0001 vs. LPS (0.1 mg/kg) AFC by ANOVA (Bonferroni). Effect of the CM of human MSCs pretreated with a KGF siRNA on alveolar fluid clearance (B). Administration of the CM of MSCs grown for 24 h pretreated with the KGF siRNA (#10818, Ambion) into the endotoxin injured lung lobe after 1 h prevented the restoration of AFC with the CM alone. The addition of recombinant KGF (100 ng) to the CM pretreated with KGF siRNA restored the decrease in AFC to control values. Data are expressed as mean AFC ± SD, n = 4–5 lungs; *, P < 0.0012 vs. control lobe by ANOVA (Bonferroni).