Table 4.

Associations of UGT1A1 tagging SNPs with serum total bilirubin levels in septic patients: Linear regression analysis

LD block	Tagging SNPs	Bilirubin levels by genotypesa			Univariate analysis			Stepwise multivariate analysis
		0	1	2	Estimates (SE)	p value	FDR p	Estimates (SE)	p value	FDR p
	rs3755319	282	513	204
		1.64 ± 0.26	1.62 ± 0.16	1.86 ± 0.24	0.0534 (0.0199)	0.0073	0.024	0.0493 (0.0171)	0.0043	0.005
	rs887829	438	455	108
		1.60 ± 0.19	1.60 ± 0.18	2.26 ± 0.37	0.0694 (0.0208)	0.0009	0.0045	0.0609 (0.0178)	0.0001	0.0005
	rs6742078	436	456	109
		1.58 ± 0.18	1.60 ± 0.18	2.18 ± 0.37	0.0709 (0.0207)	0.0006	0.0045	0.0696 (0.0178)	0.0001	0.0005
	rs3771342	757	227	21				-
		1.75 ± 0.15	1.36 ± 0.13	2.02 ± 1.29	−0.0220 (0.0282)	0.436	0.110	-	NS	-
	rs17864705	870	122	8				-
		1.64 ± 0.13	1.72 ± 0.30	4.61 ± 3.34	0.0608 (0.0375)	0.105	0.210	-	NS	-
	rs1018124	870	114	7				-
Block 1		1.68 ± 0.13	1.43 ± 0.19	4.50 ± 3.85	0.0172 (0.0390)	0.660	0.943	-	NS	-
Block 2	rs11888492	773	218	13				-
		1.67 ± 0.14	1.58 ± 0.27	3.06 ± 1.70	−0.0002 (0.0300)	0.884	0.982	-	NS	-
	rs8330	601	328	73				-
		1.75 ± 0.17	1.41 ± 0.15	2.02 ± 0.58	− 0.0103 (0.0218)	0.637	0.943	-	NS	-
	rs1500482	620	335	49				-
		1.71 ± 0.17	1.45 ± 0.15	2.55 ± 0.84	0.0003 (0.0230)	0.989	0.989	-	NS	-
	rs4663972	610	341	55				-
Block 3		1.76 ± 0.17	1.35 ± 0.14	2.62 ± 0.77	−0.0070 (0.0230)	0.761	0.951	-	NS	-

Abbreviations: LD, linkage disequilibrium; SE, standard error; FDR, false discovery rate.

^aData are n or mean ± SD; genotype 0, 1, 2 represent the wildtype, heterozygotes, and homozygotes, respectively. Missing genotyping is not included.