Table 2. Association of SNP markers within the linkage disequilibrium block on chromosome 11q24.1 with pathological myopia in Japanese population.

				Meta-analysisc		First stage (N = 1,231)				Second stage (N = 1,510)
SNP ID	Positiona	Ref.b	Var.b	P-value	OR (95%CI)d	Ref. allele freq.		Nominal P	OR (95%CI)d	Ref. allele freq.		Nominal P	OR (95%CI)d
						Case (N = 297)	Control (N = 934)			Case (N = 533)	Control (N = 977)
rs577948	121535400	A	G*	2.22×10−7	1.37 (1.21–1.54)	0.40	0.50	2.80×10−5	1.50 (1.24–1.81)	0.42	0.48	1.42×10−3	1.29 (1.11–1.50)
rs11218544	121544262	T*	G	5.48×10−6	1.33 (1.18–1.51)	0.70	0.61	7.90×10−5	1.50 (1.23–1.83)	0.66	0.61	8.94×10−3	1.24 (1.06–1.44)
rs10892819	121579254	T	G*	0.04	1.15 (1.01–1.31)	0.69	0.75	2.98×10−3	1.36 (1.11–1.67)	0.72	0.73	0.74	1.03 (0.87–1.22)
rs11218553	121590345	A	G*	8.28×10−3	1.18 (1.04–1.34)	0.60	0.67	1.77×10−3	1.36 (1.12–1.65)	0.66	0.68	0.39	1.07 (0.91–1.26)

^aThe position of markers on chromosome 11 refers to NCBI Build 36.1.

^bRef. and Var. are the reference and variant nucleotides, respectively, that are defined on the reference sequence of NCBI Build 36.1.

^cStatistical results using the Mantel-Haenzel method as a fixed-effect model were shown.

^dOdds ratios (ORs) were calculated for the causative allele (indicated with an asterisk).