Skip to main content
. 2009 Aug 27;28(20):3145–3156. doi: 10.1038/emboj.2009.244

Figure 2.

Figure 2

Effects of ADARs on functional activities of mature miRNAs processed from pri-mir-376a2. (A) Inhibition of 3′ miRNA activity. A value more than 1 means that the miRNA is less active when the ADAR is present than when the pri-mir-376a2 is expressed alone. (B) Retargeting of 3′ miRNA activity. A value less than 1 means that the miRNA is more active in the presence of the ADAR than when the pri-mir-376a2 is expressed alone. Pre-edited mir-376a2 (a177g) indicates a construct expressing pri-mir-376a2 with the +44 site (position 177) mutated from an adenosine to a guanosine. (C) Inhibition of 5′ miRNA activity. (D) Retargeting of 5′ miRNA activity. The activity for pre-edited mir-376a2 (a137g) is from a construct expressing pri-mir-376a2 with the +4 site (position 137) mutated from an adenosine to a guanosine.