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. Author manuscript; available in PMC: 2009 Nov 19.
Published in final edited form as: J Am Chem Soc. 2008 Oct 28;130(46):15405–15419. doi: 10.1021/ja803575y

Figure 9.

Figure 9

Distribution of hydrogen bond donor and acceptor side chains in a representative structure of potassium channels, KirBac1.1 (PDB ID: 1P7B). The orientation of the channel is as viewed from its extra-cellular end. The selectivity filter, which provides the backbone carbonyl oxygens to form 8-fold K+ binding sites, is colored green. The side chains of amino acids H, R, K, N, Q, T, Y, W, S and C that contain hydrogen bond donors and do not belong to the selectivity filter are illustrated as sticks and colored blue. The side chains of amino acids D and E that contain hydrogen bond acceptors are colored red. In the crystallographic configuration, all relevant side chain hydrogen bond donor groups are at a distance of at least 6.8 Å from the coordinating carbonyl oxygens of the selectivity filter.