Figure 2.

R50 quantitation of DCE-MRI data of KCI-18 KTs. (A) The R50 value is derived from CIAUC curves (as shown for control mouse) and corresponds to the Gd concentration at which 50% of the pixels have been included. (B) R50 of KTs from three mice per treatment group. (C) R50 of contralateral NK from the same three mice per treatment group shown in panel B. (D) NR50 of KT versus NK: NR50 represents normalization of R50 values of KTs relative to R50 values of contralateral NK calculated as [R50_KT - R50_NK] / R50_NK for each mouse and shown for three mice per group. (E) NR50 of KT_SU versus KT_CONT: Normalization of R50 values of KTs from mice treated with sunitinib (KT_SU) relative to the mean R50 values of KTs from control mice (KT_CONT) calculated as [R50 KT_SU - R50 KT_{mean cont}] / R50 KT_{mean cont} for each mouse and shown for three mice per treatment group. (F) NR50 of NK_SU versus NK_CONT: Normalization of R50 values of NKs of mice treated with sunitinib relative to the mean R50 values of NKs from control mice calculated as [R50 NK_SU - R50 NK_{mean cont}] / R50 NK_{mean cont} for each mouse and shown for three mice per treatment group. Data are presented for three mice per treatment group from the same experiment shown in Figure 1.