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. Author manuscript; available in PMC: 2010 Aug 14.
Published in final edited form as: Circ Res. 2009 Jul 16;105(4):365–374. doi: 10.1161/CIRCRESAHA.109.199919

Figure 4.

Figure 4

Nrf2 mediates the cardioprotective effects of H2S. (A) Representative immunoblots and (B) densitometric analysis of cardiac Trx1 and HO-1 from the hearts of Nrf2 deficient (Nrf2 KO) mice ± H2S. (C) Myocardial infarct size and (D) circulating levels of troponin-I were measured 24 hr after LCA ischemia in Wild-Type (WT) and Nrf2 KO mice receiving either vehicle or H2S PC (100 μg/kg) treatment. Nrf2 KO mice experienced exacerbated myocardial injury when compared to wild-type mice. However, no differences in myocardial infarct size or circulating troponin-I levels were observed in Nrf2 KO following H2S PC treatment. Numbers inside bars indicate the number of animals that were investigated in each group. *p<0.05, **p<0.01 vs. Sham or WT.