Table 1. Expression status of SHIP and PTEN and mutational status of SHIP1 and PIK3CA in cell lines and normal's.

cell line	cell type	\|----PIK3CA mutations----\|		SHIP1 mRNA	SHIP1 protein	SHIP1 mutation (unique)	PTEN protein	p-PTEN protein	p-Akt protein
cell line	cell type	PIK3CA exon 9	PIK3CA exon 20	SHIP1 mRNA	SHIP1 protein	SHIP1 mutation (unique)	PTEN protein	p-PTEN protein	p-Akt protein
HSB	T-ALL	wt	wt	+^ˆ	+	no	+	+	-
CEM	T-ALL	wt	wt	-/+	-/+^*	codon 278	-	-	-
Molt4	T-ALL	wt	wt	+	+	no	-	-	+
Molt16	T-ALL	wt	wt	+	+	no	-	-	+
Jurkat	T-ALL	wt	wt	+	-	codon 345, 1133 & ×12	-	-	+
Supt3	T-ALL	nd	nd	+	+	no	+	+	-
SB	B-precursor ALL	wt	wt	+	+	no	+	+	+
WI-L2	B-cell leukemia	nd	nd	+	+	no	+	+	-
RPMI 8866	B-cell leukemia	nd	nd	+	+	no	+	+	-
K562	CML	wt	wt	+	-	no	+	-	-
HL60	AML	wt	wt	-/+	+^*	no	+	+	-
Ramos	B-cell leukemia	wt	wt	+	+	no	+	nd	nd
MNC	normal PBLs	wt	wt	+	+	no	+	nd	nd
Thy	normal thymocytes	wt	wt	+	+^*	no	+	+	-

a second band of lower molecular weight is detected in these samples;

^ˆ

-, -/+, +; undectable, weakly detectable and moderate to high gene or protein expression, respectively;