Table 2. Mutational and Polymorphisms of SHIP1 in cell lines and normals.

The codon 345 null mutation found in Jurkat is found on the same allele as codon 1133 CCG (Pro) and exon 12 wild-type, while the codon 345 wild-type genotype cosegregated with codon 1133 CTG (Leu) and the exon 12 deletion.

codon	change	conservative	reported?	cell line (genotype)
162	ACA (T)-->ACG (T)	yes	no	Molt4 (A/G)
272	TCA (S) --> TCG (S)	yes	no	SB (A/G), K562 (A), Ramos (G), Molt4 (A/G), Molt16 (G), CEM (A/G), Jurkat (G), Thy (G), MNC (A/G)
278	GTC (V) --> ATC (I)	yes	no	CEM (G/A)
345	CAT (Q) --> TAG (stop)	no	no	Jurkat (C/T)
346	CTC (L) -->CTG (L)	yes	yes	SB (C/G), K562 (C), Ramos (C), Molt4 (C/G), Molt16 (C/G), CEM (C), Jurkat (G), Thy (G), MNC (C/G)
362	ACA (T) --> ACG (T)	yes	no	SB (A/G), Jurkat (G), Thy (A/G)
413	47bp deletion	no	no	Jurkat
1036	CAG (Q) --> AGG (R)	yes	no	MNC (A/G)
1086	ACG (T) --> ACA (T)	yes	yes	Ramos (G/A), Jurkat (G/A)
1133	CCG (P) --> CTG (L)	no	no	Jurkat (C/T)
1168	CAT (H) -->TAT (Y)	no	yes	Ramos (C/T), Jurkat (C/T)