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. 2009 Aug 10;119(9):2807–2817. doi: 10.1172/JCI39366

Figure 1. Atf4 inactivation increases glucose tolerance.

Figure 1

(A) Photograph of representative fat pad (16 weeks of age) and histogram showing fat pad weight over body weight in WT and Atf4–/– mice. (B and C) Blood glucose and serum insulin levels in WT and Atf4–/– mice at indicated ages. (D) Results of GSIS test in WT and Atf4–/– mice. (E) Insulin expression in pancreas of WT and Atf4–/– mice. (F) GTT in WT and Atf4–/– mice. (G and H) ITT and PTT in WT and Atf4–/– mice. (I) Insulin target gene and insulin sensitivity marker gene expression in Atf4–/– liver or cultured hepatocytes. (J) Phosphorylation of Akt in Atf4–/– liver (upper panels) or cultured hepatocytes (lower panels) at basal and insulin-stimulated conditions. (K) Insulin sensitivity marker gene expression in muscle and white adipose tissue (WAT) in Atf4–/– mice. (L) Phosphorylation of Akt in muscle in Atf4–/– mice at basal (upper panel) and insulin-stimulated (lower panel) conditions. Analysis of 8-week-old Atf4–/– mice is shown in D–L. Images in J and L were grouped from different parts of the same gel and film. Error bars show mean + SEM. **P < 0.01; *P < 0.05, WT versus Atf4–/– mice.