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. 2009 Aug 3;119(9):2758–2771. doi: 10.1172/JCI39162

Figure 8. Sirt3 enhances the synthesis of the antioxidants, MnSOD and catalase.

Figure 8

(A) Level of induction of mRNA of MnSOD and Cat in rat cardiomyocytes infected with Ad.Sirt3 or Ad.Smut viruses. Values are mean ± SEM of triplicates (*P < 0.01) (B) Western analysis of MnSOD and catalase levels in cardiac extracts of different group of mice (2 hearts in each group). (C) Western analysis of MnSOD levels from different groups of mice subjected to ISO-mediated cardiac hypertrophy. (D) Enzymatic activities of MnSOD and catalase in hearts of different groups of mice, subjected to chronic infusion of vehicle, Ang II, or ISO (mean ± SEM, n = 6; *P < 0.01). Sirt3 overexpression prevented the agonist-mediated decline of cardiac levels of MnSOD and catalase.