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. 2009 Aug 17;119(9):2634–2647. doi: 10.1172/JCI38864

Figure 5. Hemodynamic measurements.

Figure 5

(A and B) In vivo blood pressure and heart rate measurements by telemetry. (A) Boxes show blood pressure amplitudes, with upper line representing systolic pressure and lower line, diastolic pressure; error bars indicate SEM. Systolic blood pressure was significantly reduced in miR-143/145–deficient mice during day- and nighttime periods (n = 6 WT and n = 7 KO, **P < 0.01), while diastolic pressure did not differ significantly between genotypes. (B) No difference in heart rate was observed between genotypes. (C) During isoflurane anesthesia, angiotensin II induced a larger increase in systolic blood pressure in WT (n = 12) than in KO mice (n = 13) (**P < 0.01, ***P < 0.001). (D) Acute inhibition of ACE by captopril lead to a greater decrease in diastolic pressure in miR-143/145–deficient animals (n = 11 WT and n = 13 KO, **P < 0.01). Error bars indicate ± SEM.