Figure 2.

Results of sequence alignment between the three PD-resistant prions (top) and the eight PD-prone prions (identified by the PDB ID for the protein).

^aPositions are encoded with respect to the huPrP.

^b“Conservation” line shows positions (black squares with the corresponding residues shown in bold) that were significant based on the conservation of amino acids.

^c“Exch. group” line shows positions (black squares with the corresponding residues underlined) that were significant based on the conservation of amino acids grouped in exchange groups.

^d“Feature sel.” line shows positions (black squares with the corresponding residues denoted by dotted line boxes) that were significant based on the feature selection.