Table 1.
Drosophila glutamate receptor-associated protein homologs.
| Protein | Accession number | Proposed function | Drosophila homolog | % Identity/positives |
|---|---|---|---|---|
| 4.1 N | Q9H4G0 | May provide a link between AMPARs and the cytoskeleton by binding to GluR1 (Shen et al. 2000) | Cora | 57.8/73.5 |
| AMPAR Binding Protein | AF090113.1 | Protein scaffold that binds to the PDZ domain of GluR2 (Srivastava and Ziff, 1999) | GRIP | 30.9/49.0 |
| AKAP 79/150 | NM_133515.1 | Anchor kinases and phosphatases and binds to SAP97 (Colledge et al. 2000) | None | |
| Adenomatous polyposis coli (APC) | NM_000038.3 | Involved in AMPAR clustering possibly by its interaction with PSD-95 (Senda et al. 2005; Shimomura et al. 2007) | APC | 53.1/63.5 |
| AP-2, μ2 | NM_001025205.1 | Binds to cytoplasmic tail of AMPARs to promote endocytosis of receptors (Osterweil et al. 2005; Kastning et al. 2007) | AP-50 | 87.2/94.3 |
| Actinfilin | NM_145671.1 | Targets KARs for degradationn by binding to both GluR6 and Cullin 3 (Salinas et al. 2006) | CG15097 | 54.4/71.4 |
| β-catenin | NM_007614.2 | Forms a complex with N-cadherin and AMPARs possibly regulating surface expression of AMPARs (Nuriya and Huganir, 2006) | Arm | 66.3/76.7 |
| cGMP-dependent protein kinase II (cGKII) | Z36276.1 | Increases extrasynaptic surface expression of AMPARs by binding to GluR1 CTD (Serulle et al. 2007) | For Pkg21D | 50.2/68.7
45.4/64.1 |
| Dynamin-3 | NM_015569.2 | Maintains level of synaptic AMPARs by positioning endocytic proteins near the PSD (Lu et al. 2007) | Shi | 69.6/81.9 |
| GIT-1 | Q9Z272 | Involved in AMPAR trafficking by forming a complex with AMPARs, KIF1A, GRIP, and liprin-α (Shin et al. 2003; Lu et al. 2007) | CG16728 | 44.1/59.2 |
| GRIP-associated protein 1 (GRASP-1) | NM_207672.1 | RasGEF that binds to GRIP and JNK and regulates synaptic targeting of AMPARs (Ye et al. 2000; Ye et al. 2007) | CG31784 | 25.2/47.3 |
| GRIP | NM_021150.1 | Scaffolding protein that binds to GluR2 and GluR3 (Dong et al. 1997) | GRIP | 56.1/81.7 |
| Hsp90 | S45392.1 | Required for constitutive cycling of AMPARs (Gerges et al. 2004b) | Hsp83 | 70.7/79.7 |
| JNK | AB005665.1 | Acts on GluR2 (long isoform) and GluR4 to regulate cell surface expression of AMPARs (Zhu et al. 2005; Thomas et al. 2008) | Bsk | 77.7/87.2 |
| KIF1A | Q12756 | Involved in AMPAR trafficking by forming a complex with AMPARs, GIT-1, GRIP, and liprin-α (Shin et al. 2003; Lu et al. 2007) | Unc-104 | 55.2/68.7 |
| KIF17 | AB001424.1 | Required for localization of KARs by binding to GluR6 and KA2 (Kayadjanian et al. 2007) | Klp64D | 57.5/71.2 |
| Kalirin | NM_032062.1 | RhoGEF that interacts with GluR1 and regulates AMPAR insertion in response to activity (Xie et al. 2007) | Trio | 41.6/60.7 |
| KRIP6 | Q56A24 | Regulates KARs by binding to GluR6 (Laezza et al. 2007) | Dbo CG3571 | 35.9/50.6
32.6/50.2 |
| Lin-10 | NM_025187.3 | Involved in AMPAR trafficking by binding to PDZ domain (Stricker and Huganir, 2003) | CG7083 | 51.9/67.9 |
| Liprin-α | BC034046.1 | Involved in AMPAR trafficking by forming a complex with AMPARs, KIF1A, GIT-1, and GRIP (Shin et al. 2003; Lu et al. 2007) | Liprin-α | 47.8/60.2 |
| Myosin Va | NM_000259.2 | Required for transport of AMPARs during synaptic activity (Correia et al. 2008) | Didum | 39.5/57.6 |
| Myosin Vb | NM_001080467.1 | Regulates AMPAR surface expression by associating with GluR1 (Lise et al. 2006) | Didum | 42.8/60.3 |
| Myosin VI | NM_004999.3 | Involved in AMPAR endocytosis (Osterweil et al. 2005) and forms a complex with GluR1 and SAP-97 (Wu et al. 2002) | Jar | 53.2/71.5 |
| N-cadherin | AB017695.1 | Forms a complex with neural plakophilin-related arm protein (NPRAP), ABP, and GRIP to anchor AMPARs (Silverman et al. 2007) | CadN | 29.0/44.4 |
| Neuronal-activity related pentraxin (NARP) | S82649.1 | Associate with GluR1- containing AMPARs and may play a role in clustering of AMPARs (O’Brien et al. 1999; O’Brien et al. 2002) | B6 | 29.9/46.2 |
| NEEP21 | NM_024128.3 | Component of neuronal endosomes that is necessary for the recycling of AMPARs (Steiner et al. 2005; Kulangara et al. 2007) | None | |
| NPRAP | Q9UQB3 | Forms a complex with N-cadherin, ABP, and GRIP to anchor AMPARs (Silverman et al. 2007) | P120ctn | 46.2/62.9 |
| NSF | AL603829.5 | Promotes constitutive cycling of AMPARs (Nishimune et al. 1998) by disrupting GluR2 and PICK1 (Hanley et al. 2002) | Nsf2 Comt | 60.1/74.4
59.7/74.0 |
| PICK1 | AB026491.1 | Promotes internalization of GluR2-containing AMPARs (Perez et al. 2001; Terashima et al. 2004) | PICK1 | 60.8/76.3 |
| Rab8 | AF498943.1 | Involved in constitutive cycling and delivery of AMPARs to membrane surface (Gerges et al. 2004a; Brown et al. 2007) | Rab8 | 79.2/88.4 |
| Rab11 | P62494 | Responsible for delivery of GluR1-containing receptors to the synapse (Park et al. 2004; Brown et al. 2007) | Rab11 | 85.5/90.2 |
| RIL | Y08361.1 | Links internalized GluR1- containing receptors to actin cytoskeleton (Schulz et al. 2004) | CG30084 | 41.2/51.0 |
| SAP97 | NM_012788.1 | Scaffolding protein that binds to GluR1 (Leonard et al. 1998) | Dlg1 | 53.9/68.6 |
| Shank | AF133301.1 | Scaffolding protein that helps position AMPAR endocytic machinery at the PSD (Lu et al. 2007) | Prosap | 50.6/67.2 |
| SNAP (β isoform) | P28663 | Mediates disassembly of GluR2-PICK1 complex (Hanley et al. 2002) | Snap | 61.6/78.2 |
| SUMO | P63166 | Modifies GluR6 to promote endocytosis of KARs (Martin et al. 2007) | Smt3 | 52.3/70.5 |
| SynGAP | NM_001113409.1 | Involved in AMPAR trafficking to synapse (Rumbaugh et al. 2006) | CG32560 | 37.7/55.1 |
| γ2 (Stargazin) | NM_006078.2 | Involved in localization of AMPARs to synapse and delivery to cell surface (Chen et al. 2000) | Stg1 | 26.1/38.9 |
| γ3 (TARP) | NM_006539.2 | Required for expression of AMPARs on cell surface (Tomita et al. 2003) | Stg1 | 27.7/42.9 |
| γ8 (TARP) | NM_ 080696.2 | Required for expression of AMPARs on cell surface (Tomita et al. 2003) | Stg1 | 28.9/43.0 |
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