Table 2.

Multivariate Logistic Regression Model for Pathologic Complete Response

Variable	Odds Ratio	95% CI	P
Diabetes, yes v no	0.44	0.20 to 1.00	.05
Age, ≥ 50 years v < 50 years	0.89	0.70 to 1.14	.36
Metformin use, yes v no	2.95	1.07 to 8.17	.04
Clinical stage, III v I and II	0.60	0.47 to 0.77	< .001
Tumor grade, 3 v 1 and 2	2.66	1.89 to 3.73	< .001
Hormone receptor status, ER positive and/or PR positive v both negative	0.34	0.26 to 0.44	< .001
HER-2 status, positive v negative	2.38	1.86 to 3.05	< .001
Neoadjuvant taxane use, yes v no	2.30	1.65 to 3.20	< .001
BMI
Overweight v normal/underweight	0.77	0.56 to 1.04	.09
Obese v normal/underweight	1.16	0.88 to 1.55	.299

Abbreviations: ER, estrogen receptor; PR, progesterone receptor; HER-2, human epidermal growth factor receptor 2; BMI, body mass index.