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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Int J Cancer. 2009 Oct 1;125(7):1685–1691. doi: 10.1002/ijc.24477

Table 2.

Association between the +331 G/A PR polymorphism and postmenopausal breast cancer risk, among all cases and limited to ER+ or PR+ tumors only

PR genotype Cases, n (%) Controls, n (%) OR (95%CI)1 OR (95%CI)2
All cases 1664 2391
GG 1463 (88%) 2174 (91%) 1.0 (ref) 1.0 (ref)
AG 195 (12%) 202 (8%) 1.44 (1.15-1.79) 1.34 (1.06-1.69)
AA 6 (0.4%) 15 (1%) 0.62 (0.24-1.62) 0.89 (0.32-2.52)
GG 1463 (88%) 2174 (91%) 1.0 (ref) 1.0 (ref)
AG + AA 201 (12%) 217 (9%) 1.38 (1.11-1.71) 1.31 (1.04-1.65)
ER+ tumors only3
GG 941 (89%) 2174 (91%) 1.0 (ref) 1.0 (ref)
AG + AA 116 (11%) 217 (9%) 1.24 (0.97-1.57) 1.30 (0.95-1.78)
PR+ tumors only4
GG 767 (89%) 2174 (91%) 1.0 (ref) 1.0 (ref)
AG + AA 98 (11%) 217 (9%) 1.28 (1.00-1.65) 1.30 (0.93-1.82)
1

Conditional logistic regression for all cases. Unconditional logistic regression for ER+ and PR+ tumors only adjusted for matching variables: age, date blood draw, time at blood draw, fasting status and PMH use at diagnosis.

2

Conditional logistic for all cases adjusted for age at menarche, age at menopause, age at first birth/parity, BMI at age 18, weight gain since age 18, history of benign breast disease, first-degree family history of breast cancer, and alcohol consumption. Unconditional logistic regression for ER+ and PR+ tumors only, adjusting for the matching variables and age at menarche, age at menopause, age at first birth/parity, BMI at age 18, weight gain since age 18, history of benign breast disease, first-degree family history of breast cancer, and alcohol consumption.

3

ER- tumors = 232, ER status unknown = 29.

4

PR- tumors = 388, PR status unknown = 33.