Table 3.
Association between +331G/A PR polymorphism and risk of postmenopausal breast cancer by postmenopausal hormone (PMH) status and type of PMH used
| PMH use status | GG | AG+GG | |||||
|---|---|---|---|---|---|---|---|
| Cases, n (%) | Controls, n (%) | OR (95%CI)1 | Cases, n (%) | Controls, n (%) | OR (95%CI) | P - int2 | |
| Never | 258 (83%) | 607 (92%) | 1.00 (ref) | 53 (17%) | 50 (8%) | 2.57 (1.64-4.02) | |
| Past | 336 (90%) | 574 (91%) | 1.00 (ref) | 39 (10%) | 54 (9%) | 1.23 (0.77-1.97) | |
| Current | 804 (89%) | 891 (90%) | 1.00 (ref) | 97 (11%) | 97 (10%) | 1.14 (0.84-1.56) | |
| Estrogen alone | 373 (89%) | 445 (91%) | 1.00 (ref) | 47 (11%) | 45 (9%) | 1.49 (0.95-2.36) | |
| Estrogen + progesterone | 355 (90%) | 355 (90%) | 1.00 (ref) | 38 (10%) | 41 (10%) | 0.78 (0.47-1.27) | |
| Other | 76 (86%) | 91 (89%) | 1.00 (ref) | 12 (14%) | 11 (11%) | 1.50 (0.48-4.68) | |
| 0.02 | |||||||
1
Unconditional logistic regression adjusted for age, date blood draw, age at menarche, age at menopause, age at first birth/parity, BMI at age 18, weight gain since age 18, history of benign breast disease, first-degree family history of breast cancer, and alcohol consumption.
2
P - int = P for interaction based on likelihood ratio test comparing unconditional logistic regression models with and without interaction terms between PMH use status (never, past, current) and genotype (GG, AG+GG)(degrees of freedom = 2).