Fig. 5.

Gland-hair metaplasia in mouse plantar region and supernumerary hair follicles. (A,A′) The inhibition of the BMP pathway in K14-Nogginmouse leads to the formation of hair follicles (A′) instead of sweat glands (A). After Plikus et al. 2004. Reprinted with permission from the American Society for Investigative Pathology. (B–D′) The sustained expression of beta-catenin leads not only to the formation of precocious and supplementary hair pelage (compare B and B′, C and C′), but also to the formation of hair buds on the plantar surface (compare D and D′). The arrows and arrowheads attract attention on normal and abnormal skin pattern. After Nähri et al. 2008. Reproduced with permission of the Company of Biologists. swg, sweat gland; h, hair. Bars: A,A′: 100 µm, B,B′: 2 mm, C,C′: 200 µm, D,D′: 4 mm.