Table 1.
Defects in let-7, miR-125 Mutants
| Defect | Description |
|---|---|
| Eclosion | Low eclosion frequency (Table 2) |
| NMJ size | Fewer, smaller boutons in dorsal abdominal (DAb) muscles (Figure 5) |
| Lifespana | Reduced longevity (Figure 1H) |
| Fertilitya | Sterile, morphologically normal gonads, no oviposition |
| Locomotion | No flight, uncoordinated movements, tremblingb |
| Behavior | Aberrant grooming, aborted courtship, male-male courtship |
| Wing and cell size | Small wings, small cells (Figure 2) |
a
Both males and females.
b
Some defects increase in severity with age.