Figure 2.

Cell survival predicted as an exponential function of peak intracellular DOX concentration, using data from Kerr et al. [23]. Using this fit and the drug uptake model gives good agreement to a second data-set published in the same paper, but a rather poor agreement with a third. (A) Cell survival as a function of intracellular drug concentration. (B) Predicted cell survival versus the actual cell survival for cells exposed to different concentrations of DOX for 1 hour. (C) Predicted cell survival versus the actual cell survival for cells exposed to 5 μm/ml of DOX for 15, 30, 45, and 60 minutes.