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. Author manuscript; available in PMC: 2009 Sep 1.
Published in final edited form as: Science. 2008 Dec 5;322(5907):1543–1546. doi: 10.1126/science.1163086

Figure 1. CYK-4 GAP domain mutants phenocopy Centralspindlin loss-of function.

Figure 1

A) Residues changed in CYK-4 and ZEN-4 mutant proteins. B) The E448K and T546I substitutions destabilize CYK-4 GAP domain structure. C) Plot of mean furrow diameter versus time. Error bars=SEM. D) Time-lapse montage of the furrow region in embryos expressing a GFP::plasma membrane marker. Series begin at anaphase onset. Scale bar, 20μm.